616400-M

Tranilast

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

• 別名: Tranilast, N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
• 実験式（ヒル表記法）: C₁₈H₁₇NO₅
• CAS番号: 53902-12-8
• 分子量: 327.33
• MDL番号: MFCD00864787
• UNSPSCコード: 51111800

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: pale yellow
• 溶解性: DMSO: 200 mg/mL
• 保管温度: −20°C
• InChI: 1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
• InChI Key: NZHGWWWHIYHZNX-CSKARUKUSA-N

詳細

詳細

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca²⁺ mobilization in vascular smooth muscle.

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca²⁺ mobilization in vascular smooth muscle.

生物化学的／生理学的作用

Primary Target
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, aliquot and freeze (-20°C).

その他情報

Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable