565773

γ-Secretase Inhibitor XII

The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: γ-Secretase Inhibitor XII, Z-IL-CHO
• 実験式（ヒル表記法）: C₂₀H₃₀N₂O₄
• 分子量: 362.46
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ₄₀ IC₅₀ = 11.5 µM; Aβ₄₂ IC₅₀ = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).

A cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM) and in cultured cells that stably over-express APP695 (Aβ₄₀ IC₅₀ = 11.5 µM; Aβ₄₂ IC₅₀ = 8.3 µM). Also shown to block the generation of γCTF (γ-secretase-generated carboxy-terminal fragment).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Aβ40 in vitro

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

Z-Ile-Leu-CHO

その他情報

Weijzen, S., et al. 2002. Nat. Med.8, 979.
McLendon, C., et al. 2000. FASEB J.14, 2383.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable