5.30463

Dopamine Receptor D3 Antagonist II, YQA14

• 別名: Dopamine Receptor D3 Antagonist II, YQA14, D3R Antagonist
• 実験式（ヒル表記法）: C₂₃H₂₇ClN₄O₃
• CAS番号: 1221408-42-9
• 分子量: 442.94
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: powder
• 有効性: 0.068 pM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: tan
• 溶解性: DMSO: 100 mg/mL
• 保管温度: 2-8°C

詳細

詳細

A highly potent and selective antagonist of dopamine D3 receptors. Has two binding sites on human cloned D3 receptors (K_i = 0.0680 pM high affinity and 2.11 nM low affinity).

An orally bioavailable benzoxazolone carboxamide derivative that acts as a highly potent and selective antagonist of dopamine D3 receptors. Has two binding sites on human cloned D3 receptors (K_i = 0.0680 pM high affinity and 2.11 nM low affinity). Displays >150-fold greater selectivity for D3 over D2 receptors and about 1000-fold selectivity over other dopamine receptors. Exhibits strong anti-addiction profile and reduces self administration of cocaine in rodent models (6.25 to 25 mg/kg in rats) without affecting their sucrose water self-administration and locomotor activity.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
D3

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C

その他情報

Song, R., et al. 2014. Neuropharm.77, 398.
Song, R., et al. 2011. Addiction Biol.17, 259.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable