529579

PP1 Analog

• 別名: PP1 Analog, 4-Amino-1- tert-butyl-3-(1ʹ-naphthyl)pyrazolo[3,4-d]pyrimidine, 1-Na PP1, 1-NA-PP1
• 実験式（ヒル表記法）: C₁₉H₁₉N₅
• CAS番号: 221243-82-9
• 分子量: 317.39
• UNSPSCコード: 12352202

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: off-white
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)
• InChI Key: XSHQBIXMLULFEV-UHFFFAOYSA-N

詳細

詳細

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). Also available in InSolution format (Cat. No. 529605).

A potent, reversible, ATP-competitive, cell-permeable and selective inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). Also available in InSolution format (Cat. No. 529605).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
I338G mutant v-Src

Product competes with ATP.

Reversible: yes

Target IC₅₀: 1.5 nM against I338G mutant v-Src; 1.0 µM against wild-type v-Src; 600 nM against wild-type Fyn

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.

その他情報

Bishop, A.C., et al. 2000. Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

法的情報

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable