528151

PARP Inhibitor VIII, PJ34

InSolution, ≥98%

• 別名: InSolution PARP Inhibitor VIII, PJ34, 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl, 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl
• 実験式（ヒル表記法）: C₁₇H₁₇N₃O₂ · xHCl
• 分子量: 295.34 (free base basis)
• MDL番号: MFCD17014689
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 輸送温度: ambient
• 保管温度: −70°C
• SMILES記法: O=C(CN(C)C)NC(C=C1)=CC(C2=C3C=CC=C2)=C1NC3=O

詳細

詳細

A water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC₅₀ = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC₅₀ = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528150, 528151 ) is also available.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PARP

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

物理的形状

A 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O.

再構成

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

その他情報

Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med.7, 255.
Garcia-Soriano, F.G., et al. 2001. Nature Med.7, 108.
Mabley, G.J., et al. 2001. Inflamm. Res.50, 561.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable