5.09890

Benztropine

• 別名: Benztropine, Benzatropine, Cogentin
• 実験式（ヒル表記法）: C₂₁H₂NO · xCH₄O₃S
• CAS番号: 132-17-2
• 分子量: 284.25 (free base basis)
• MDL番号: MFCD00074784
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 保管温度: 2-8°C
• SMILES記法: [S](=O)(=O)(O)C.N1([C@@H]2CC[C@@H]1CC(C2)OC(c4ccccc4)c3ccccc3)C
• InChI: 1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m1./s1
• InChI Key: CPFJLLXFNPCTDW-STYNFMPRSA-N

詳細

詳細

A brain penetrating azabicyclo[3.2.1]octane derivative with anti-cholinergic and anti-histaminergic properties. Acts as an antagonist of muscarinic M1 and M3 receptors induces robust differentiation of oligodendrocytes precursor cell differentiation (OPC; EC₅₀ = 500 nM) and promotes myelination. Reduces the expression of Notch 1 in immature OPC and reduces the levels of cyclin D1 and D2 and c-Fos and c-Jun indicating its inhibitory effect on cell cycle progression. Shown to reduce the severity of the acute phase of multiple sclerosis and virtually eliminates the relapse phase in animal models. Significantly reduces the severity in the experimental autoimmune encephalomyelitis (EAE) model of relapsing-remitting multiple sclerosis when administered alone or co-administered with FTY720 (Cat. No. 344597).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Muscarinic M1/M3

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Toxic (F)

その他情報

Deshmukh, V.A, et al. 2013. Nature 502,327.
Doshay, L.J., et al. 1956. J Am Med Assoc.162, 1031.

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法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H302 - H311 + H331
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable