5.05877

(S)-(-)-Raclopride

• 別名: (S)-(-)-Raclopride, Dopamine Receptor D2 Antagonist, (S)-Raclopride, Raclopride
• 実験式（ヒル表記法）: C₁₅H₂₀Cl₂N₂O₃
• CAS番号: 84225-95-6
• 分子量: 347.24
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 100 mM; ethanol: 25 mM
• 保管温度: 2-8°C
• InChI: 1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m1/s1
• InChI Key: WAOQONBSWFLFPE-SECBINFHSA-N

詳細

詳細

D₂-like dopamine receptor antagonist targeting D₂R (pKi =8.0), D₃R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D₂ like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D₂ Receptor selectivity in various preps shows IC₅₀ values around 32 nM.

生物化学的／生理学的作用

Reversible: yes

警告

Toxicity: Standard Handling (A)

その他情報

Dang, Y. H. et al. 2010. Neurosci.169, 1872.

Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable