5.05762

(+/-)-Clopidogrel Hydrogensulfate

• 別名: (+/-)-Clopidogrel Hydrogensulfate, Purinergic P2Y12 Receptor Antagonist, (+/-)-Clopidogrel, Plavix
• 実験式（ヒル表記法）: C₁₆H₁₆ClNO₂S · xH₂SO₄
• CAS番号: 135046-48-9
• 分子量: 321.82 (free base basis)
• MDL番号: MFCD05865229
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 25 mg/mL
• 保管温度: 2-8°C
• SMILES記法: [S](=O)(=O)([O-])O.[s]1c2c(cc1)C[N+H](CC2)C(c3c(cccc3)Cl)C(=O)OC
• InChI: 1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)
• InChI Key: FDEODCTUSIWGLK-UHFFFAOYSA-N

詳細

詳細

A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y₁₂ receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.

生物化学的／生理学的作用

Primary Target
P2Y₁₂

Reversible: no

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Liu, O., et al. 2012. PLoS One.7, e51707.

Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05,GHS09
• シグナルワード: Danger
• 危険有害性情報: H314 - H411
• 注意書き: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
• 保管分類コード: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable