47589-M

Mitomycin C, Streptomyces caespitosus

• 別名: Mitomycin C, Streptomyces caespitosus, Mitocin C, MMC
• 実験式（ヒル表記法）: C₁₅H₁₈N₄O₅
• CAS番号: 50-07-7
• 分子量: 334.33
• MDL番号: MFCD00078109
• UNSPSCコード: 12352200

特性

• アッセイ: ≥95% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: blue-violet
• 溶解性: water: 1 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
• InChI Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N

詳細

詳細

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G₂ phase.

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

物理的形状

Provided as 2 mg antibiotic and 48 mg NaCl.

再構成

Following reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.

その他情報

Kruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst.87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res.83, 899.
Malkinson, A.M., et al. 1992. Cancer Res.52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol.174, 5471.
Tomasz, M., et al. 1987. Science235, 1204.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H351
• 注意書き: P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 2
• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable