365252

Gö 7874, Hydrochloride

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC).

• 別名: Gö 7874, Hydrochloride, MLCK Inhibitor III
• 実験式（ヒル表記法）: C₂₇H₂₆N₄O₄ · xHCl
• CAS番号: 287935-76-6
• 分子量: 470.52 (free base basis)
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: amber
• 溶解性: DMSO: 25 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of protein kinase C (IC₅₀ = 4 nM for rat brain PKC). Inhibits protein kinase A (IC₅₀ = 510 nM), protein kinase G (IC₅₀ = 4.8 µM), and myosin light chain kinase (IC₅₀ = 120 nM) at much higher concentrations.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PKC

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4 nM against rat brain PKC

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Kleinschroth, J., et al. 1995. Bioorg. Med. Chem. Lett.5, 55.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable