361568

GSK-3β Inhibitor XXV

The GSK-3β Inhibitor XXV controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: GSK-3β Inhibitor XXV, 5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC
• 実験式（ヒル表記法）: C₁₅H₁₁ClN₄O₃
• CAS番号: 1257256-44-2
• 分子量: 330.73
• MDL番号: MFCD22683811
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: CC(C=C1)=C(Cl)C=C1NC2=NN=C(C3=CC=C(C=C3)[N+]([O-])=O)O2

詳細

詳細

A blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC₅₀ = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Khanfar, M.A., et al. 2010. J. Med. Chem.53, 8534.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable