251600

Daidzein

Inactive analog of Genistein.

• 別名: Daidzein, 4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
• 実験式（ヒル表記法）: C₁₅H₁₀O₄
• CAS番号: 486-66-8
• 分子量: 254.24
• MDL番号: MFCD00016954
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: off-white
• 溶解性: DMSO: 200 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
• InChI Key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N

詳細

詳細

Inactive analog of Genistein (Cat. No. 345834). Blocks the G₁ phase of the cell cycle in Swiss/3T3 cells by inhibiting casein kinase II activity. Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC₅₀= 45 µM and 75 µM, respectively).

Inactive analog of genistein (Cat. No. 345834). Blocks the G₁ phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Inhibits epidermal growth factor (EGF) receptor autophosphorylation (IC₅₀ >300 µM). Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC₅₀= 45 µM and 75 µM, respectively).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
MiaPaC-2, PANC-1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 45 µM, 75 µM for inhibiting the growth of MiaPaC-2 and PANC-1 cells, respectively

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.

その他情報

Guo, J-M., et al. 2004. World J. Gastroenterol.10, 860.
Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol.7, 637.
Akiyama, T., et al. 1987. J. Biol. Chem.262, 5592.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable