197900

BEC, Hydrochloride

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5).

• 別名: BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)
• 実験式（ヒル表記法）: C₅H₁₂BNO₄S · xHCl
• 分子量: 193.03 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (NMR)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: water: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
arginase 1, arginase 2

Product does not compete with ATP.

Reversible: no

Target K_i: 310 nM for human recombinant type II arginase, pH 7.5

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.

その他情報

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3