175580

Angiogenesis Inhibitor

The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Angiogenesis Inhibitor, ( Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one, (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
• 実験式（ヒル表記法）: C₁₂H₉N₃O
• CAS番号: 186611-44-9
• 分子量: 211.22
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
hEGF-R tyrosine kinase activity

Product competes with ATP.

Reversible: no

Target IC₅₀: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

その他情報

Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable