14-522-M

ABL (T315I) Protein, active

recombinant, expressed in baculovirus infected Sf21 cells

• UNSPSCコード: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

特性

• product name: Abl (T315I) Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation. For use in Kinase Assays.
• 由来生物: human
• リコンビナント: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 121 kDa
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• NCBIアクセッション番号: NM_005157.3; NM_007313.2
• UniProtアクセッション番号: P00519

詳細

詳細

N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation

Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.

Product Source: Expressed by baculovirus in Sf21 insect cells

アプリケーション

Research Category
代謝

炎症及び免疫

Research Sub Category
肥満

代謝障害

骨粗しょう症

関節炎

生物化学的／生理学的作用

Protein Target: Abl

Target Sub-Family: TK

包装

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.

品質

routinely evaluated by phosphorylation of Abltide

物理的形状

Ni²⁺/NTA-agarose

保管および安定性

6 months at -70°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.