07-1601

Anti-IRAK1 Antibody, CT

from rabbit

• 別名: interleukin-1 receptor-associated kinase 1, Pelle homolog
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_001020413.1
• UniProtアクセッション番号: P51617
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... IRAK1(3654)

詳細

詳細

IRAK1, also known as Interleukin-1 receptor associated kinase 1, belongs to the tyrosine kinase related (TKL) family and is involved with mRNA stabilization and activation of NF-kappa B. IRAK1 is located in all tissue as 2 isoforms, with 1 binding quickly and then degrading while isoform 2 is activated by kinase, resulting in a slower more sustained response to cytokines. Phosphorylation of IRAK1 leads to recruitment of the adapter protein PELI1. IRAK1 utilizes 2 pathways, the first one allows for mediation of IL-1 inflammatory responses when TRAF6 is bound, which activates NF-kappa B, thereby inhibiting I kappa B alpha. A second pathway does not involve TRAF6 and results in the stabilization of mRNA.

特異性

This antibody recognizes the C-terminal region of IRAK1.

免疫原

Epitope: C-terminus

KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of IRAK1.

アプリケーション

Research Category
炎症及び免疫

Research Sub Category
免疫シグナル伝達

This Anti-IRAK1 Antibody, C-terminus is validated for use in WB for the detection of IRAK1.

品質

Evaluated by western blot in jurkat lysate.

Western Blot Analysis: A 1:50-1:500 dilution of this antibody detected IRAK1 on jurkat lysate.

ターゲットの説明

~77 kDa

物理的形状

Protein G Purified

Format: Purified

Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.

保管および安定性

Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

アナリシスノート

Control
Jurkat lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable