由来生物
rabbit
抗体製品の状態
purified antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
rat, canine, mouse, chicken, bovine, human
メーカー/製品名
Upstate®
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SIK2(23235)
詳細
QIK (Qin-induced Kinase, SNF1LK2, SIK2, Salt-induced protein Kinase 2) is a Ser/Thr kinase that belongs to the AMPK/SNF1 kinase family. QIK is phosphorylated and activated by the tumor suppressor LKB1 when in complex with the pseudokinase STRAD and the scaffolding protein MO25. QIK has been found in adipocytes where it is known to phosphorylate a few substrates that include insulin receptor substrate 1 (IRS1) on Ser794 and TORC2 (also known as CRTC2 and not to be confused with the mTOR complex) on Ser171. The phosphorylation of TORC2 results in its translocation to the nucleus where it binds to CREB.
特異性
Close homology with mouse, rat, chicken, dog, and cow.
Detects QIK
免疫原
KLH-conjugated synthetic peptide corresponding to the C-term of human QIK.
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Anti-QIK (SIK2) Antibody is an antibody against QIK (SIK2) for use in WB.
品質
Western Blot Analysis:
This lot detected QIK at 1:1,000-1:2,000 dilution in HeLa lysates via SDS-PAGE and transferred to PVDF (Immobilon-P).
This lot detected QIK at 1:1,000-1:2,000 dilution in HeLa lysates via SDS-PAGE and transferred to PVDF (Immobilon-P).
ターゲットの説明
104 kDa
物理的形状
Protein A purified
Format: Purified
Protein A purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 15mM NaCl, and 0.05% NaN3 with 30% glycerol.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
アナリシスノート
Control
HeLa Cell Lysate
HeLa Cell Lysate
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
07-1378:
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Salt-inducible kinase in steroidogenesis and adipogenesis.
Trends in Endocrinology and Metabolism, 15, 21-26 (2004)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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