A-144

Acylcarnitines Mix 2 (C4,iC4,C5,iC5,C6,C8,C10,C12,C14,C18) solution

100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid), certified reference material, ampule of 1 mL, Cerilliant^®

• 実験式（ヒル表記法）: C₂₅H₄₉NO₄
• 分子量: 427.66
• UNSPSCコード: 41116107

特性

• グレード: certified reference material
• 品質水準: 300
• 形状: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 組成: Butyryl-L-carnitine, 100 μg/mL ; Decanoyl-L-carnitine, 100 μg/mL ; Hexanoyl-L-carnitine, 100 μg/mL ; Isobutyryl-L-carnitine, 100 μg/mL ; Isovaleryl-L-carnitine, 100 μg/mL ; Lauroyl-L-carnitine, 100 μg/mL ; Myristoyl-L-carnitine, 100 μg/mL ; Octanoyl-L-carnitine, 100 μg/mL ; Stearoyl-L-carnitine, 200 μg/mL ; Valeryl-L-carnitine, 100 μg/mL
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 100-200 μg/mL (90:10 Methanol: 1% aqueous formic acid)
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: clinical testing
• フォーマット: multi-component solution
• 保管温度: −70°C

詳細

詳細

A Certified Spiking Solution^® of routinely tested Butyryl-L-Carnitine, Isobutyryl-L-Carnitine, Valeryl-L-Carnitine, Isovaleryl-L-Carnitine, Hexanoyl-L-Carnitine, Octanoyl-L-Carnitine, Decanoyl-L-Carnitine, Lauroyl-L-Carnitine, Myristoyl-L-Carnitine and Stearoyl-L-Carnitine at concentrations of 100-200 μg/mL. Acylcarnitines are biomarker for many inborn errors of metabolism that cause several metabolic diseases and are routinely tested in newborn screening programs. This multi-component mix is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls, calibrators, and linearity standards for LC-MS/MS assays; as system tuning/suitability standards; linearity verification; and internal proficiency testing. The stable, quantitative solution format provides significant benefits to the user such as convenience of use, material savings, and increased efficiency of labor. Certified concentration values for each component provides increased efficiency from less time remaking pools due to dilution errors or rerunning samples.

アプリケーション

• Metabolic Disorder Biomarker Development: Acylcarnitines are crucial in diagnosing very long-chain acyl-CoA dehydrogenase deficiency. This research utilizes acylcarnitine profiles to improve understanding and treatment approaches for metabolic disorders, employing mass spectrometry metabolites for precise analysis (Bleeker JC et al., 2020).


• High-Purity Acylcarnitine Standards in Research: The study demonstrate the simultaneous extraction of metabolomes and lipidomes, including acylcarnitines, using ultra-high performance liquid chromatography/mass spectrometry. This methodology supports high-precision studies in fatty acid oxidation and metabolic assay development (Chen S et al., 2013).


• Application in Inborn Errors of Metabolism Assay: The research investigates how dietary bioactive polyphenols affect the mitochondrial carnitine acylcarnitine carrier, showcasing the utility of acylcarnitines in studying the impact of natural compounds on metabolic pathways, vital for understanding inborn errors of metabolism (Console L et al., 2019).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225 - H301 + H311 + H331 - H370
• 注意書き: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup