860532P

C8 Ceramide-1-Phosphate (d18:1/8:0)

N-octanoyl-ceramide-1-phosphate (ammonium salt), powder

• 別名: Ammonium (2S,3R,4E)-3-hydroxy-2-(octanoylamino)octadec-4-en-1-yl hydrogen phosphate
• 実験式（ヒル表記法）: C₂₆H₅₅N₂O₆P
• CAS番号: 474943-70-9
• 分子量: 522.70
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• 形状: powder
• 包装: pkg of 1 × 1 mg (860532P-1mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 860532P
• 脂質タイプ: sphingolipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCC)=O)COP([O-])(O)=O.[NH4+]
• InChI: 1S/C26H52NO6P.H3N/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(28)24(23-33-34(30,31)32)27-26(29)22-20-17-8-6-4-2;/h19,21,24-25,28H,3-18,20,22-23H2,1-2H3,(H,27,29)(H2,30,31,32);1H3/b21-19+;/t24-,25+;/m0./s1
• InChI Key: WDZBNEWCUHJJDF-AAMXSQEYSA-N

詳細

詳細

C8 Ceramide-1-Phosphate (d18:1/8:0) or N-octanoyl-ceramide-1-phosphate is a synthetic short-chain ceramide.

Ceramide-1-phosphate is synthesized from ceramide by the phosphorylation reaction catalyzed by ceramide kinase (CerK).

アプリケーション

C8 Ceramide-1-Phosphate (d18:1/8:0) has been used as one of the authentic standards to validate selected metabolites in metabolomic study of vertebrate metamorphosis.

C8 Ceramide-1-Phosphate (d18:1/8:0) or N-octanoyl-ceramide-1-phosphate has been used:

• in lipid preparation to treat endothelial colony-forming cells (ECFCs) for nuclear morphology analysis
• for the validation of C8 ceramide-1-phosphate metabolite to study its effects on the metabolic pathways of Rana catesbeiana during metamorphosis
• to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue

生物化学的／生理学的作用

Ceramide-1-phosphate (C1P), as a lipid derived secondary messenger plays a vital role in various cellular processes such as inflammation, cell proliferation, differentiation and apoptosis. It is mitogenic for fibroblasts. C1P is also implicated in the modulation of macrophage chemotaxis. It promotes cell-survival by inhibiting the enzyme acid sphingomyelinase (SMase).

包装

5 mL Amber Glass Screw Cap Vial (860532P-1mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3