QBD10867

SPDP-dPEG^®₃₆-NHS ester

>95% (HPLC)

• 別名: OPSS-PEG₁₅₀₀-NHS ester, OPSS-PEG₃₆-NHS ester, SPDP-PEG-NHS ester, SPDP-PEG₃₆-NHS ester
• 実験式（ヒル表記法）: C₈₇H₁₆₁N₃O₄₁S₂
• 分子量: 1969.33
• MDL番号: MFCD21363283
• UNSPSCコード: 12352108
• NACRES: NA.22

特性

• アッセイ: >95% (HPLC)
• 形状: solid or viscous liquid
• 反応適合性: reaction type: Pegylations
• ポリマー構造: shape: linear; functionality: heterobifunctional
• 輸送温度: ambient
• 保管温度: −20°C

詳細

特徴および利点

SPDP-dPEG₃₆-NHS ester is an amphiphilic, water-soluble PEGylation reagent that is designed to crosslink amines and free thiols. SPDP (also referred to as orthopyridyl disulfide, or OPSS) reacts with sulfhydryl groups to form disulfide bonds. The N-hydroxysuccinimidyl (NHS) ester reacts with free amines to form amide bonds. The single molecular weight, discrete chain length polyethylene glycol (dPEG) chain is 115 atoms (137.8 Å) long. SPDP-dPEG36-NHS ester is used like SPDP and its related hydrophobic products. However, the water-soluble dPEG product prevents hydrophobicity-triggered precipitation of compounds to which it is conjugated. SPDP-dPEG₃₆-NHS ester is a monodisperse equivalent of the polymeric PEG₁₅₀₀.

法的情報

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable