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Biochemistry, 27(13), 4923-4933 (1988-06-28)
To establish the state of protonation of quinonoid species formed nonenzymically from pyridoxal phosphate (PLP) and diethyl aminomalonate, we have studied absorption spectra of the rapidly established steady-state mixture of species. We have evaluated the formation constant and the spectrum
Molecular pharmaceutics, 14(9), 3105-3113 (2017-08-15)
Intraperitoneal administration of chemotherapeutics is expected for the treatment of peritoneally disseminated gastric cancer because of poor migration of the drugs from the systemic circulation to the peritoneal cavity. In this study, for intraperitoneal delivery of cisplatin (CDDP), we developed
Reaction control in the organocatalytic asymmetric one-pot, three-component reaction of aldehydes, diethyl alpha-aminomalonate and nitroalkenes: toward diversity-oriented synthesis.
Chemistry (Weinheim an der Bergstrasse, Germany), 14(32), 9873-9877 (2008-10-04)
Organic letters, 3(18), 2911-2914 (2001-09-01)
[reaction: see text]. Nitrogen-containing tethered diacids, easily prepared by reductive alkylation of diethyl aminomalonate or ethyl cyanoglycinate, undergo double Michael reactions with 3-butyn-2-one to give highly functionalized and substituted piperidines (pipecolic acid derivatives) with surprisingly high stereoselectivity. The heterocyclic double
The Journal of organic chemistry, 67(1), 298-300 (2002-01-05)
The azomethine ylide derived from the condensation of diethyl aminomalonate with paraformaldehyde undergoes 1,3-dipolar cycloadditions with acrylate and propiolate derivatives. Contrary to a previous report, these reactions yield mixtures of regioisomers generally favoring the 2,2,3-trisubstituted product. However, the relative quantity
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