936464

3-(3-Fluoro-4-piperidin-4-ylphenylamino)piperidine-2,6-dione hydrochloride

≥95%

• 別名: 2,6-Piperidinedione, 3-[[3-fluoro-4-(4-piperidinyl)phenyl]amino]-, hydrochloride
• 実験式（ヒル表記法）: C₁₆H₂₀FN₃O₂ · xHCl
• CAS番号: 2654822-04-3
• 分子量: 305.35 (free base basis)
• UNSPSCコード: 12161600
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder or crystals
• 色: off-white to beige
• 保管温度: 2-8°C
• SMILES記法: Cl.O=C1NC(=O)C(NC2=CC=C(C(F)=C2)C3CCNCC3)CC1
• InChI: 1S/C16H20FN3O2.ClH/c17-13-9-11(19-14-3-4-15(21)20-16(14)22)1-2-12(13)10-5-7-18-8-6-10;/h1-2,9-10,14,18-19H,3-8H2,(H,20,21,22);1H
• InChI Key: VJQKECGXGMCYHY-UHFFFAOYSA-N

詳細

アプリケーション

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachment via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

targeted protein degradation
When used with other protein degrader building blocks
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

その他情報

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable