934313

Thalidomide-4-hydroxyacetate

≥95.0%

• 別名: 2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid, 2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl)oxyacetic acid
• 実験式（ヒル表記法）: C₁₅H₁₂N₂O₇
• CAS番号: 1061605-21-7
• 分子量: 332.26
• MDL番号: MFCD31560477
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• ligand: thalidomide
• 品質水準: 100
• アッセイ: ≥95.0%
• 形状: powder or crystals
• 色: off-white to light yellow
• 保管温度: 2-8°C
• SMILES記法: O=C(O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

詳細

アプリケーション

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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その他情報

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法的情報

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H312,H360D
• 注意書き: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• 危険有害性の分類: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable