926019

TissueFab^® bioink kit

(Gel)ma Fibronection -Vis/405 nm, low endotoxin

• UNSPSCコード: 12352201
• NACRES: NA.25

特性

• フォーム: viscous liquid (gel)
• サイズ: 10 mL
• 不純物: <5 cfu/mL Bioburden; <50 EU/mL Endotoxin
• 色: pale yellow to colorless
• pH: 6.5-7.5
• 粘度: 3-30 cP
• アプリケーション: 3D bioprinting

詳細

詳細

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. Fibronectin is a multifunctional glycoprotein which exists as two major isoforms, one soluble and one insoluble form. The former is present in plasma, whereas the insoluble form resides in tissues and extracellular matrix (ECM) of cartilage. Fibronectin is known to contain integrin binding sequences which facilitate cell-matrix interactions.

アプリケーション

The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation. Gelatin methacrylate based bioinks have been used to bioprint osteogenic [1], chondrogenic [2-3], hepatic [4-6], adipogenic [7], vasculogenic [8], epithelial [6], endothelial [9-10], cardiac valve [11], skin [12], tumor [10] and other tissues and constructs. Fibronectin plays an essential role in multiple biological functions such as, angiogenesis, cell migration and differentiation and wound healing. Fibronectin has been used in tissue engineering applications for wound healing and angiogenesis[13], bone repair [14] and studying mechanotransduction[15].

特徴および利点

In addition to fast gelation, the methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.

法的情報

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable