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About This Item
実験式（ヒル表記法）:
C6H7N5
CAS番号:
分子量:
149.15
MDL番号:
UNSPSCコード:
12352005
PubChem Substance ID:
NACRES:
NA.22
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アッセイ
97%
形状
solid
mp
346-350 °C
SMILES記法
Cn1cnc2ncnc(N)c12
InChI
1S/C6H7N5/c1-11-3-10-6-4(11)5(7)8-2-9-6/h2-3H,1H3,(H2,7,8,9)
InChI Key
HCGHYQLFMPXSDU-UHFFFAOYSA-N
アプリケーション
<ul>
<li><strong>Biomarkers of Cigarette Smoking and DNA Methylating Agents:</strong> Study on 7-Methyladenine highlights its role as a biomarker of DNA damage from exposure to methylating agents (Harroun et al., 2017).</li>
</ul>
<li><strong>Biomarkers of Cigarette Smoking and DNA Methylating Agents:</strong> Study on 7-Methyladenine highlights its role as a biomarker of DNA damage from exposure to methylating agents (Harroun et al., 2017).</li>
</ul>
包装
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
666548-100MG:
666548-BULK:
666548-VAR:
666548-500MG:
B Tudek et al.
Acta biochimica Polonica, 46(3), 785-799 (2000-03-04)
The most abundant lesion formed in DNA upon modification with methylating agents 7-methylguanine, under alkaline conditions is converted into 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7MeGua). We have previously shown that treatment of dimethylsulfate methylated DNA with NaOH creates mutagenic base derivatives leading to a
H G Mandel et al.
Analytical biochemistry, 217(2), 292-297 (1994-03-01)
We have developed a procedure for isolating and quantifying 7-methyladenine from rat urine following the administration to the rat of methylating agents, such as dimethylnitrosamine. Urinary 7-methyladenine and its trideutero isomer, added as an internal standard, were precipitated with silver
Shinji Tokuda et al.
Bioscience, biotechnology, and biochemistry, 76(4), 828-830 (2012-04-10)
Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC(50) value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect
H G Mandel et al.
Carcinogenesis, 15(7), 1393-1398 (1994-07-01)
Earlier studies showed that urine of rats which had been injected with the methylating agent N-[3H-methyl]-N-nitrosourea contained a previously undetected metabolic product, 7-[3H-methyl]adenine. This methylpurine, undoubtedly derived from alkylation of nucleic acids followed by depurination, was not labeled when 14C-methyl-labeled
H G Mandel et al.
Carcinogenesis, 10(4), 757-762 (1989-04-01)
Relatively simple and rapid analytical procedures involving two sequential HPLC separations were developed for the isolation of methylated purines in the urine of rats administered radiolabeled methylating carcinogens. Following a dose of [3H]N-methyl-N-nitrosourea (MNU), 7-methyl-adenine (m7Gua) was detected by chromatography
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