TNNT3
troponin T type 3 (skeletal, fast)
別名:
TNTF
Species:
Human TNNT3 (7140), Mouse Tnnt3 (21957), Rat Tnnt3 (24838), chicken TNNT3 (395761), dog TNNT3 (475996), domestic cat TNNT3 (101091149), cow TNNT3 (282096), sheep TNNT3 (101104467), Goat TNNT3 (100861247), domestic guinea pig Tnnt3 (100734707) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(7140) Summary: The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
- Mouse(21957) troponin T3, skeletal, fast
- Rat(24838) troponin T type 3 (skeletal, fast)
- chicken(395761) troponin T type 3 (skeletal, fast)
- dog(475996) troponin T type 3 (skeletal, fast)
- domestic cat(101091149) troponin T type 3 (skeletal, fast)
- cow(282096) troponin T type 3 (skeletal, fast)
- sheep(101104467) troponin T type 3 (skeletal, fast)
- Goat(100861247) troponin T type 3 (skeletal, fast)
- domestic guinea pig(100734707) troponin T type 3 (skeletal, fast)
- Domestic Rabbit(100009527) troponin T type 3 (skeletal, fast)
- naked mole-rat(101718573) troponin T type 3 (skeletal, fast)
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗TNNT3抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
western blot
western blot
抗TNNT3抗体 ウサギ宿主抗体, IgG fraction of antiserum,
交差性
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat
アプリケーション
western blot
抗TNNT3抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Monoclonal Anti-TNNT3, (C-terminal) antibody produced in mouse, clone 1H4, ascites fluid,
交差性
human, rat
アプリケーション
ELISA
western blot
western blot
モノクロナール抗トロポニンT マウス宿主抗体, clone JLT-12, ascites fluid,
交差性
bovine, chicken, rabbit, rat
アプリケーション
immunohistochemistry
western blot
western blot
esiRNA
製品番号
詳細
Species