MED12
mediator complex subunit 12
別名:
ARC240, CAGH45, FGS1, HOPA, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
Species:
Human MED12 (9968), Mouse Med12 (59024), Rat Med12 (679693), sheep MED12 (101123015), naked mole-rat Med12 (101714647), Domestic Rabbit MED12 (100350850), domestic guinea pig Med12 (100713106), Zebrafish med12 (566632), cow MED12 (520974), Horse MED12 (100056909) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(9968) Summary: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
- Mouse(59024) mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
- Rat(679693) mediator complex subunit 12
- sheep(101123015) mediator complex subunit 12
- naked mole-rat(101714647) mediator complex subunit 12
- Domestic Rabbit(100350850) mediator complex subunit 12
- domestic guinea pig(100713106) mediator complex subunit 12
- Zebrafish(566632) mediator of RNA polymerase II transcription, subunit 12 homolog
- cow(520974) mediator complex subunit 12
- Horse(100056909) mediator complex subunit 12
- domestic cat(101090673) mediator complex subunit 12
- dog(480952) mediator complex subunit 12
- chicken(422210) mediator complex subunit 12
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗MED12 ウサギ宿主抗体, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗MED12 ウサギ宿主抗体, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry