CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
別名:
CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Species:
Human CDKN1A (1026), Mouse Cdkn1a (12575), Rat Cdkn1a (114851), sheep CDKN1A (100302083), domestic guinea pig Cdkn1a (100720449), naked mole-rat Cdkn1a (101710552), Zebrafish cdkn1a (100151416), cow CDKN1A (513497), domestic cat CDKN1A (493943), dog CDKN1A (474890)
UniProtKB ID:
遺伝子ID:
- Human(1026) Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
- Mouse(12575) cyclin-dependent kinase inhibitor 1A (P21)
- Rat(114851) cyclin-dependent kinase inhibitor 1A
- sheep(100302083) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- domestic guinea pig(100720449) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- naked mole-rat(101710552) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- Zebrafish(100151416) cyclin-dependent kinase inhibitor 1A
- cow(513497) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- domestic cat(493943) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- dog(474890) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗p21抗体 クローン5G7 ZooMAb® ウサギ・モノクローナル, recombinant, expressed in HEK 293 cells,
交差性
human, mouse
アプリケーション
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-p21/WAF1/Cip1 Antibody, Upstate®, from mouse,
交差性
human, mouse
アプリケーション
immunoprecipitation (IP)
western blot
western blot
Anti-p21/WAF1/Cip1 Antibody, clone CP74, clone CP74, Upstate®, from mouse,
交差性
human
アプリケーション
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Proteins
製品番号
詳細
Species
p21CIP1、GSTタグ融合 ヒト, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human