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Safety Information

SRP6518

Sigma-Aldrich

Plasminogen from human plasma

≥95% (SDS-PAGE)

Synonym(s):

PLG

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

90.0 – 92.0 kDa

packaging

pkg of 1 mg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PLG(5340)

General description

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.

Biochem/physiol Actions

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Physical form

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

JAN Code

SRP6518-1MG:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.
Lee SH, et al.
Biomaterials, 29, 2962-2968 (2008)
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
McColl BK, et al.
The Journal of Experimental Medicine, 198, 863-868 (2003)
Genetic linkage between lipoprotein (a) phenotype and a DNA polymorphism in the plasminogen gene.
Drayna D T, et al.
Genomics, 3(3), 230-236 (1988)
Minor Role of Plasminogen in Complement Activation on Cell Surfaces.
Hyvarinen S and Jokiranta TS
PLoS ONE, 10, e0143707-e0143707 (2015)
Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo.
Inoue K, et al.
The Journal of Biological Chemistry, 274, 27069-27075 (1999)

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