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Key Documents

Safety Information

SAB5700295

Sigma-Aldrich

Anti-Phospho-EIF4EBP1-T70 antibody produced in rabbit

Synonym(s):

4E-BP1, 4EBP1, BP-1, EIF4EBP1, PHAS-I

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

12

species reactivity

mouse, human

concentration

1.78 mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

Q13541

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr70)

Gene Information

human ... EIF4EBP1(1978)

General description

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Immunogen

A synthetic phosphorylated peptide around T70 of human EIF4EBP1 (NP_004086.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB5700295-100UL:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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