O8757

Ofloxacin

fluoroquinolone antibiotic

• Synonym(s): Dextrofloxacin
• Empirical Formula (Hill Notation): C₁₈H₂₀FN₃O₄
• CAS Number: 82419-36-1
• Molecular Weight: 361.37
• MDL number: MFCD00226105
• PubChem Substance ID: 24278613

Properties

• biological source: synthetic
• Quality Level: 200
• assay: ≥99% (HPLC)
• form: powder
• solubility: 1 M NaOH: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Mode of action: DNA synthesis | interferes; enzyme | inhibits
• storage temp.: 2-8°C
• InChI: 1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
• InChI key: GSDSWSVVBLHKDQ-UHFFFAOYSA-N
• Gene Information: human ... CSNK2A1(1457) , KCNH1(3756) ; rat ... Gabra1(29705)

Description

General description

Chemical structure: fluoroquinolone

Application

Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery.

Packaging

1, 10 g in poly bottle

Biochem/physiol Actions

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which haults DNA replication and cell division. Ofloxacin has been shown to convert LytA from the inactive E-form to the active C-form. It is a chiral molecule that inhibits pneumococcal cell wall-degrading virulence factors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves