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Safety Information

N8159

Sigma-Aldrich

Albumin, Nitrated from bovine serum

lyophilized powder

Synonym(s):

Nitrated BSA

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About This Item

CAS Number:
9048-46-8
MDL number:
MFCD03454307
UNSPSC Code:
12352202
NACRES:
NA.41

biological source

bovine

Quality Level

200

form

lyophilized powder

technique(s)

immunoblotting: suitable

UniProt accession no.

P02769

shipped in

wet ice

storage temp.

−20°C

Gene Information

bovine ... ALB(280717)

General description

Albumin, Nitrated (Nitrated BSA), is prepared by chemical modification of bovine serum albumin (BSA) by peroxynitrite. Peroxynitrite (ONOO-), a potent oxidant is an important member of the family of reactive oxygen and nitrogen species.

Application

Positive control in immunoblotting assays for Anti-Nitrotyrosine (Sigma Product Number N 0409).

Biochem/physiol Actions

Peroxynitrite promotes the nitration of tyrosine residues in proteins linked, oxidation of redox metal centers, DNA, lipids and nitrosation of cysteine residues in proteins, suggesting that peroxynitrite plays a major role in oxidative cellular damage. Peroxynitrite has been implicated in the pathogenesis of several inflammatory, infectious and degenerative human disease. These include neurological conditions such as Alzheimer′s disease, amyotrophic lateral sclerosis (ALS), the pathogenesis of asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.4

Preparation Note

Bovine serum albumin (BSA) nitrated with peroxynitrite.

Analysis Note

Does not contain sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N8159-BULK:
N8159-VAR:
N8159-.1MG-PW:
N8159-.1MG:
N8159-.2MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation
Lai H and Yen GC
Bioscience, Biotechnology, and Biochemistry, 66(1), 22-28 (2002)
The Intracellular Redox Stress Caused by Hexavalent Chromium is Selective for Proteins that Have Key Roles in Cell Survival and Thiol Redox Control
Judith M
Toxicology (2011)
Nitric oxide and peroxynitrite in health and disease
Pacher P, et al.
Physiological Reviews, 87(1), 315-424 (2007)
Péter Borbély et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-13)
Selenium (Se) enrichment of Stevia rebaudiana Bertoni can serve a dual purpose, on the one hand to increase plant biomass and stress tolerance and on the other hand to produce Se fortified plant-based food. Foliar Se spraying (0, 6, 8

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