I4401
Interferon-αA/D human
≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Synonym(s):
IFN-αA/D
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About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥95%
form
buffered aqueous solution
mol wt
19 kDa
packaging
pkg of 100K units
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IFNA2(3440)
Application
Interferon-αA/D human has been used:
- for identification of coronavirus replicase inhibitors
- in combination with ACH-806 [1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea] to study the effect on hepatitis C virus (HCV) replication
- in combination with vitamin D to check reduction in HCV protein production in cell culture
Biochem/physiol Actions
Interferon-αA/D (Bg/II), also known as Universal Type I Interferon, is an α interferon hybrid that crosses the species barrier. The Bg/II denotes the restriction enzyme site from which this hybrid is constructed from recombinant human interferons αA and αD. Interferon-αA/D has been proven to be active on many mammalian cells. It can substitute for human, monkey, mouse, bovine, rat, cat, dog, rabbit, sheep, goat, horse, pig or hamster type I interferon (α, β, ω and τ). Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes), and ruminant embryos (τ subtypes). This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Physical form
Solution in phosphate buffered saline containing 0.1% bovine serum albumin
Analysis Note
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for human interferonαA.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
I4401-BULK:
I4401-VAR:
I4401-100KU-PW:
I4401-100KU:
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