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Safety Information

I3265

Sigma-Aldrich

Interferon-γ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, suitable for cell culture

Synonym(s):

IFN-γ

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About This Item

MDL number:
MFCD00131391
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

~17 kDa

packaging

pkg of 0.1 mg

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg endotoxin

color

white

solubility

water: soluble 1.000 mL, clear, colorless

UniProt accession no.

P01579

storage temp.

−20°C

Gene Information

human ... IFNG(3458)

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Application

Interferon-γ human has been used:
  • to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
  • to analyse factors which participate in the production of antibody microarrays on glass support
  • for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge

Biochem/physiol Actions

IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.

Physical form

Lyophilized from phosphate buffered saline.

Analysis Note

The biological activity is measured by a viral resistance assay.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I3265-.1MG:
I3265-BULK:
I3265-VAR:
I3265-.1MG-PW:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M J Lappin et al.
Archives of oral biology, 61, 36-43 (2015-10-30)
To investigate the potential effects of IFN-03A5 on the responsiveness of human gingival fibroblasts to bacterial challenge. mRNA and protein expression of CD14, TLR2 and TLR4 in human gingival fibroblasts was detected by quantitative polymerase chain reaction (Q-PCR) and flow
K Pfizenmaier et al.
Cancer research, 45(8), 3503-3509 (1985-08-01)
The effect of recombinant gamma-interferon (IFN-gamma) on established human colon carcinoma cell lines as well as fresh tumor cells from colon carcinoma patients has been investigated with respect to growth inhibition, enhancement of HLA expression, and modulation of immunogenicity. A
R Pijnenborg et al.
Molecular human reproduction, 6(7), 635-641 (2000-06-29)
Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma, produced by maternal inflammatory cells, may compromise trophoblast survival at the trophoblast-maternal interface and notably in the placental bed which is invaded by trophoblast. Extracellular matrix components, e.g. fibronectin, may enhance trophoblast survival.
Marielle Kaplan et al.
Inflammation, 41(4), 1477-1487 (2018-04-25)
Arterial macrophages comprise a heterogeneous population: pro-inflammatory (M1) and anti-inflammatory (M2). Since C-reactive protein (CRP) is produced by macrophages in atherosclerotic lesions, understanding of CRP regulation in macrophages could be crucial to decipher inflammatory patterns in atherogenesis. We aimed to
Meager, A. et al.
Lymphokines and Interferons, A Practical Approach, 129-129 (1987)
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