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Key Documents

Safety Information

I8782

Sigma-Aldrich

Interferon αA from mouse

≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Synonym(s):

IFN-αA

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About This Item

MDL number:
MFCD02253032
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

mouse

Quality Level

200

recombinant

expressed in E. coli

Assay

≥95%

form

buffered aqueous solution

mol wt

20 kDa

technique(s)

cell culture | mammalian: suitable

color

colorless

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... Ifna3(110218)

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Packaging

Minimum 1x105 units/vial.

Physical form

Solution in phosphate buffered saline containing 0.1% bovine serum albumin.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon α.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I8782-BULK:
I8782-1VL:
I8782-VAR:
I8782-1VL-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCC3124
SLBV1139
062M4069V
11120601
120M1742

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Interferon standards and general abbreviations.
S Pestka
Methods in enzymology, 119, 14-23 (1986-01-01)
A convenient and rapid cytopathic effect inhibition assay for interferon.
P C Familletti et al.
Methods in enzymology, 78(Pt A), 387-394 (1981-01-01)
S Rubinstein et al.
Journal of virology, 37(2), 755-758 (1981-02-01)
A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed

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