C7698

Cycloheximide

from microbial, ≥94% (TLC)

• Synonym(s): 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Empirical Formula (Hill Notation): C₁₅H₂₃NO₄
• CAS Number: 66-81-9
• Molecular Weight: 281.35
• Beilstein: 88868
• EC Number: 200-636-0
• MDL number: MFCD00082346
• PubChem Substance ID: 24892981
• NACRES: NA.77

Properties

• biological source: microbial
• Quality Level: 200
• assay: ≥94% (TLC)
• form: powder
• solubility: ethanol: soluble, clear to hazy
• antibiotic activity spectrum: fungi; yeast
• Mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N
• Gene Information: human ... FKBP1A(2280) , PIN1(5300)

Description

Application

• In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.[1]
• It has been used to inhibit translation in mammalian cells.[2][3]
• It has been used to suppress fungal growth.[4]

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H300 - H341 - H360D - H411
• Precautionary Statements: P201 - P202 - P264 - P270 - P273 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves