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A7926

Sigma-Aldrich

Azlocillin sodium salt

Synonym(s):

D-α-([Imidazolidin-2-on-1-yl]carbonylamino)benzylpenicillin

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About This Item

Linear Formula:
C20H22N5O6SNa
CAS Number:
37091-65-9
Molecular Weight:
483.47
EC Number:
253-347-7
MDL number:
MFCD07793330
UNSPSC Code:
51282412
PubChem Substance ID:
24891295
NACRES:
NA.85

form

powder

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

room temp

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C20H23N5O6S.Na/c1-20(2)13(17(28)29)25-15(27)12(16(25)32-20)22-14(26)11(10-6-4-3-5-7-10)23-19(31)24-9-8-21-18(24)30;/h3-7,11-13,16H,8-9H2,1-2H3,(H,21,30)(H,22,26)(H,23,31)(H,28,29);/q;+1/p-1/t11-,12-,13+,16-;/m1./s1

InChI key

UVOCNBWUHNCKJM-XFAPPKAWSA-M

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General description

Chemical structure: ß-lactam

Application

Azlocillin is often used against <l>Pseudomonas aeruginosa </l>and has been used to develop novel antibiotic quantitation techniques .

Biochem/physiol Actions

Azlocillin is a semisynthetic penicillin and a β-lactam antibiotic. It acts by inhibition of penicillin-binding protein (PBP)-dependent bacterial cell wall synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Precautionary Statements

P280 - P302 + P352

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A7926-250MG:
A7926-1G-PW:
A7926-VAR:
A7926-1G:
A7926-5G-PW:
A7926-BULK:
A7926-5G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase.
Andrea M. Hujer, Malgosia Kania, et. Al
Journal of Affective Disorders, 49, 612-618 (2005)
Venkata Raveendra Pothineni et al.
Scientific reports, 10(1), 3798-3798 (2020-03-04)
Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients treated with antibiotic therapy
A Weber et al.
Antimicrobial agents and chemotherapy, 24(5), 750-753 (1983-11-01)
We describe a rapid, precise, and simple procedure for the quantitation of azlocillin in serum and in aqueous solutions by high-pressure, reverse-phase liquid chromatography. This method uses a single precipitation step, detection by dual-wavelength monitoring (220 and 254 nm), and

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