69479

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

for GC derivatization, LiChropur^™, ≥98.5%

• Synonym(s): MSTFA, N-Trimethylsilyl-N-methyl trifluoroacetamide
• Linear Formula: CF₃CON(CH₃)Si(CH₃)₃
• CAS Number: 24589-78-4
• Molecular Weight: 199.25
• Beilstein: 1941550
• EC Number: 246-331-6
• MDL number: MFCD00000411
• PubChem Substance ID: 329761689
• NACRES: NA.22

Properties

• Quality Level: 100
• grade: for GC derivatization
• vapor density: >1 (vs air)
• vapor pressure: 8.8 mmHg ( 27 °C)
• assay: ≥98.5% (GC); ≥98.5%
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.38 (lit.); n20/D 1.380
• bp: 130-132 °C (lit.)
• density: 1.075 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CN(C(=O)C(F)(F)F)[Si](C)(C)C
• InChI: 1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
• InChI key: MSPCIZMDDUQPGJ-UHFFFAOYSA-N

Description

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylating reagent.

Application

Learn more in the Product Information

Suitable for the derivatization of amines, amino acids, carboxyl, hydroxyamines, indolalkylamine, n-nitrosoamino acids, nucleosides, phenolalkylamines, serotonin and tryptamine.

MSTFA may be used in silylation procedure to detemine steroid hormones 17α-ethinylestradiol (EE2) and estrone using GC-MS. MSTFA along with Trimethylsilyl chloride (TMCS) in eithyl acetate, acetonitrile and dichloromethane solvents leads to formation of trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) derivatives.

Other Notes

Powerful silylating agent

Reagent for N-acetyl-N, trifluoroacetyl, trimethylsilyl, N-trimethylsilyl-N-trifluoroacetyl, and O-trimethylsilyl (TMS)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Warning
• Hazard Statements: H226 - H315 - H319 - H335
• Precautionary Statements: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 77.0 °F - closed cup
• Flash Point(C): 25 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves