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394866

Supelco

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

synthesis grade

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
Beilstein:
1941550
EC Number:
246-331-6
MDL number:
MFCD00000411
UNSPSC Code:
12000000
PubChem Substance ID:
24864622
NACRES:
NA.22

grade

for GC derivatization
synthesis grade

Quality Level

100

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

Assay

≥98%

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

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General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Application

Silylating agent used to form volatile derivatives for GC-MS analysis.
Improved silylation procedure for simultaneous detection of steroid hormones 17-α-ethynylestradiol and estrone.

Other Notes

Reagent for trimethylsilyl.

related product

Product No.
Description
Pricing

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

78.8 °F - closed cup

Flash Point(C)

26 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

394866-10X1ML:
394866-25ML:
394866-BULK:
394866-10ML:
394866-1ML:
394866-VAR:
394866-5ML:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG8677
BCCG8773
BCCG0949
BCCD6442
BCCC5543

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Tina Kosjek et al.
Environment international, 31(5), 679-685 (2005-05-25)
Pharmacologically active substances used to treat human and animal illnesses can enter the aquatic environment via effluents from wastewater treatment plants or in the case of veterinary drugs directly through liquid manure discharge. Some of these substances enter the environment
Iria González-Mariño et al.
Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
Hee-Kyung Jeon et al.
Journal of chromatography. A, 1131(1-2), 192-202 (2006-08-08)
A novel method has been developed to simultaneously determine and quantify seven organic UV filters employing liquid (solid)-liquid extraction, derivatization with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and gas chromatography with mass spectrometric detection in various environmental matrices. The UV filters determined were:
Stina K Lien et al.
Journal of chromatography. A, 1247, 118-124 (2012-06-15)
GC-MS analysis of silylated metabolites is a sensitive method that covers important metabolite groups such as sugars, amino acids and non-amino organic acids, and it has become one of the most important analytical methods for exploring the metabolome. Absolute quantitative
L Damasceno et al.
Journal of mass spectrometry : JMS, 35(11), 1285-1294 (2000-12-13)
An evaluation of derivatization procedures for the detection of beta(2)-agonists is presented. The study was performed with the beta(2)-agonists bambuterol, clenbuterol, fenoterol, formoterol, salbutamol, salmeterol and terbutaline. Different derivatizating agents were employed, aiming to obtain derivatives with high selectivity to
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