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Safety Information

E-901

Supelco

Estazolam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C16H11ClN4
CAS Number:
29975-16-4
Molecular Weight:
294.74
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Clc1ccc-2c(c1)C(=NCc3nncn-23)c4ccccc4

InChI

1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

InChI key

CDCHDCWJMGXXRH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

General description

A Certified Snap-N-Spike® Solution appropriate for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing and pharmaceutical research. Estazolam is a benzodiazepine prescribed for the short-term treatment of insomnia. Sold under trade names such as ProSom or Eurodin, estazolam is often abused recreationally to achieve a high or when long-term use is continued against physician advice.

Application


  • Estazolam in environmental trace analysis: A study employing ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detailed the detection of Estazolam among other psychotropic medications in environmental samples, underscoring the method′s precision and application in monitoring environmental contamination by pharmaceutical residues (Wang et al., 2024).

  • Estazolam and insomnia post-coronavirus disease: Research analyzed insomnia prevalence among COVID-19 survivors, identifying Estazolam as part of the therapeutic regimen. This study highlights the ongoing relevance of Estazolam in addressing sleep disorders associated with long-term recovery from significant health events (Lu et al., 2024).

  • Comparative analysis of Estazolam for post-stroke insomnia: A network meta-analysis compared various treatments for post-stroke insomnia, including Estazolam, providing insights into its effectiveness relative to other therapeutic options. This study contributes to understanding optimal treatment strategies for insomnia in post-stroke patients (Song et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Alcohols
Hazardous rank II

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

E-901-1ML:4548173317687
E-901-CC:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuan Tian et al.
Journal of pharmaceutical and biomedical analysis, 47(4-5), 899-906 (2008-05-13)
A simple, rapid, sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the quantification of rupatadine in human plasma using estazolam as internal standard (IS). Following liquid-liquid extraction, the analytes were separated using a mobile
Clinical efficacies of treating refractory insomnia patients with estazolam plus alternating current magnetic field.
Zhi-Zhong Wang et al.
Chinese medical journal, 125(17), 3175-3176 (2012-08-31)
Toshiaki Aoshima et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(3), 535-538 (2003-04-15)
The effects of the cytochrome P450 (CYP)2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam were studied in 16 healthy male volunteers. The two mutated alleles (CYP2C19*2 and CYP2C19*3) causing absent CYP2C19 activity were
T Tadano et al.
Pharmacology, 62(3), 157-162 (2001-04-05)
Intraperitoneal injection of benzodiazepine receptor agonists (estazolam, zopiclone, triazolam: 0.03-0.24 mmol/kg) induces the head twitch response (HTR). The present study was undertaken to examine the possible participation of the serotonergic system in the mechanism of head twitches induced by benzodiazepine
Jun Bu et al.
Fa yi xue za zhi, 26(1), 30-32 (2010-03-18)
To study the relation between human blood estazolam concentration and neurobehavioral function. The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3 (NES-C3) and SMART EquiTest system. The neurobehavioral ability and balance function declined 1 h later
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