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  • New multicomponent approach for the synthesis of benzo[c]coumarin derivatives over MgO under solvent-free conditions.

New multicomponent approach for the synthesis of benzo[c]coumarin derivatives over MgO under solvent-free conditions.

Molecular diversity (2010-07-24)
Hassan Valizadeh, Ashraf Fakhari
ABSTRACT

In this study, a three-component one-pot synthesis of select 5-amino-6-cyano-3-hydroxybenzo[c]coumarin compounds derived from salicylaldehydes, malononitrile, and ethyl acetoacetate is reported. The reaction is conducted on grinding over MgO at room temperature resulting in good yields.

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Ethyl acetoacetate, ReagentPlus®, 99%
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