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Key Documents

1370327

USP

Lorazepam Related Compound A

United States Pharmacopeia (USP) Reference Standard

Sinonimo/i:

3-(Acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, (±)-Lorazepam

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About This Item

Formula empirica (notazione di Hill):
C17H12Cl2N2O3
Numero CAS:
Peso molecolare:
363.19
Beilstein:
764089
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

lorazepam

Produttore/marchio commerciale

USP

Controllo stupefacenti

regulated under CDSA - not available from Sigma-Aldrich Canada

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CC(=O)OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O

InChI

1S/C17H12Cl2N2O3/c1-9(22)24-17-16(23)20-14-7-6-10(18)8-12(14)15(21-17)11-4-2-3-5-13(11)19/h2-8,17H,1H3,(H,20,23)
CYDZMDOLVUBPNL-UHFFFAOYSA-N

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Lorazepam Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Lorazepam
  • Lorazepam Tablets

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Pittogrammi

Exclamation markEnvironment

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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K Liu et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(3), 609-613 (1991-05-01)
Rates of hydrolysis of racemic and enantiomeric lorazepam 3-acetates (LZA) by esterases in human and rat liver microsomes and rat brain S9 fraction were compared. LZA and its hydrolysis product were analyzed by chiral stationary phase HPLC. When rac-LZA was
Stationary ultrafiltration: a radio-tracer technique for studying stereoselective binding of racemic ligands.
M Simonyi et al.
Biochemical and biophysical research communications, 97(1), 1-7 (1980-11-17)
Application of ultrafiltration and CD spectroscopy for studying stereoselective binding of racemic ligands.
M Simonyi et al.
Biochemical and biophysical research communications, 109(3), 851-857 (1982-12-15)
I Fitos et al.
Chirality, 11(2), 115-120 (1999-02-10)
The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, especially in the presence of (+)-(S)-ibuprofen. The phenomenon is an
I Fitos et al.
Biochemical pharmacology, 35(2), 263-269 (1986-01-15)
Stereoselective binding of oxazepam, lorazepam, temazepam and methyl lorazepam as well as of their acetates to human serum albumin was investigated by different techniques. The 2'-chlorine and the N(1)-methyl substitution exert opposite effects on the antipodes. Enantiomers of oxazepam acetate

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