Y0002361

Saxagliptin

for system suitability CRS, European Pharmacopoeia (EP) Reference Standard

• Sinonimo/i: Saxagliptin hydrate, (S)-3-Hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile hydrate, BMS 477118, BMS 477118-11, BMS-477118, BMS-477118-11, BMS477118, BMS477118-11
• Formula empirica (notazione di Hill): C₁₈H₂₅N₃O₂ · H₂O
• Numero CAS: 945667-22-1
• Peso molecolare: 333.43
• Codice UNSPSC: 41116107

Proprietà

• Grado: pharmaceutical primary standard
• Produttore/marchio commerciale: EDQM
• applicazioni: pharmaceutical
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC12CC([C@@H](C(N3[C@@H](C[C@]4([C@@]3(C4)[H])[H])C#N)=O)N)(CC(C5)C2)CC5C1.O
• InChI: 1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10?,11?,12-,13+,14+,15-,17?,18?;/m1./s1; AFNTWHMDBNQQPX-NHKADLRUSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Saxagliptin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

Confezionamento

Unit quantity: 1.082mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H317 - H334 - H361fd - H372
• Consigli di prudenza: P202 - P260 - P264 - P280 - P302 + P352 - P308 + P313
• Classi di pericolo: Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT RE 1
• Codice della classe di stoccaggio: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable