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822854

TSKgel® SuperSW mAb HR (4 µm) HPLC Column

L x I.D. 30 m × 7.8 mm, diol phase

Sinonimo/i:

TSKgel® Size Exclusion (SW-Type) HPLC Column

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About This Item

Codice UNSPSC:
41115711

product name

Colonna HPLC TSKgel® per HPLC di esclusione dimensionale (Tipo SW), phase diol, L × I.D. 30 m × 7.8 mm, 4 μm particle size

Materiali

stainless steel

agenzia

suitable for USP L20
suitable for USP L59

Nome Commerciale

TSKgel®

Produttore/marchio commerciale

Tosoh SuperSW mAb HR, 22854

Parametri

≤0.5 M salt concentration
0-100% aqueous soluble organic solvents
1 mL/min flow rate
10-30 °C temperature
120 bar max. pressure

tecniche

HPLC: suitable

Lungh. × D.I.

30 m × 7.8 mm

Matrice

silica particle platform

Gruppo funzionale matrice

diol phase

Dimensione particelle

4 μm

Dimensione pori

250 Å pore size

pH di lavoro

2.5-7.5

Tecnica di separazione

size exclusion (SEC)

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Descrizione generale

The TSKgel SuperSW and UltraSW mAb columns consist of three specialized columns designed for the separation and analysis of monoclonal antibodies (mAb). While mAbs can be analyzed using many different modes of HPLC, size exclusion is best to determine the level of aggregation, dimer formation, and fragmentation, making it the best method for heterogeneity studies. TSKgel SuperSW mAb HR columns are optimized for high resolution analysis of mAb monomer and dimer; these 30 cm x 7.8 mm ID slica-based stainless steel columns offer reduced lot-to-lot variation, long column life, reduction of unspecified adsorption, and superior recovery of aggregates. The TSKgel SuperSW mAb columns utilize a unique pore-controlled technology, which produces a shallow calibration curve in the molecular weight region of a typical monoclonal antibody. The calibration curve for the TSKgel SuperSW mAb HR column is similar to that of the industry-leading TSKgel G3000SWxl column and has a shallower slope than the TSKgel UltraSW Aggregate column around the molecular weight range of gamma-globulin. This shallow calibration curve produces high resolution separations.

Applicazioni

TSKgel® superSW mAb HR HPLC column may be used in the separation of monoclonal antibodies using size exclusion chromatography (SEC).

Stato fisico

Shipped in 0.05% NaN3 and 0.1 M Na2SO4 in 0.1 M phosphate buffer, pH 6.7.

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Note legali

TSKgel is a registered trademark of Tosoh Corporation

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Oliver Seifert et al.
mAbs, 11(5), 919-929 (2019-04-06)
Multivalent mono- or bispecific antibodies are of increasing interest for therapeutic applications, such as efficient receptor clustering and activation, or dual targeting approaches. Here, we present a novel platform for the generation of Ig-like molecules, designated diabody-Ig (Db-Ig). The antigen-binding
Alexander Rau et al.
mAbs, 13(1), 1902034-1902034 (2021-03-24)
Dual targeting of surface receptors with bispecific antibodies is attracting increasing interest in cancer therapy. Here, we present a novel bivalent and bispecific antagonistic molecule (Dab-Fc) targeting human epidermal growth factors 2 and 3 (HER2 and HER3) derived from the

Articoli

Columns and Analytical Standards for Protein SEC

Size-exclusion chromatography (SEC) columns and ready-to-use standards facilitate method development and increase robustness of protein SEC methods.

Protocolli

Calibration Curves for TSKgel® SW mAb Columns

Calibration Curves for TSKgel® SW mAb Columns

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