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V6383

Sigma-Aldrich

Vinpocetine

≥98%, solid

Sinonimo/i:

(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester, Eburnamenine-14-carboxylic acid ethyl ester

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About This Item

Formula empirica (notazione di Hill):
C22H26N2O2
Numero CAS:
42971-09-5
Peso molecolare:
350.45
Numero CE:
256-028-0
Numero MDL:
MFCD00211233
Codice UNSPSC:
41106305
ID PubChem:
24278182
NACRES:
NA.77

Livello qualitativo

200

Saggio

≥98%

Stato

solid

Colore

white

Solubilità

DMSO: 5 mg/mL
H2O: insoluble

Stringa SMILE

[H][C@]12N3CCC[C@@]1(CC)C=C(C(=O)OCC)n4c2c(CC3)c5ccccc45

InChI

1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
DDNCQMVWWZOMLN-IRLDBZIGSA-N

Informazioni sul gene

human ... PDE1A(5136) , PDE1B(5153) , PDE1C(5137)

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Azioni biochim/fisiol

Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Photosensitive

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
056H0188
128H0788
099H0884
099H0883
010K1165

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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M Cataldi et al.
Biochimica et biophysica acta, 1449(2), 186-193 (1999-03-20)
The present study investigates the potential role of the Ca2+-calmodulin-dependent type I phosphodiesterase (PDE)-cGMP-protein kinase G (PKG) pathway in spontaneous [Ca2+]i oscillations in GH3 cells using fura-2 single cell videoimaging. Vinpocetine (2.5-50 microM), a selective inhibitor of type I PDE
G R Tabeeva et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(12 Pt 2), 20-30 (2013-02-08)
A search for approaches to treatment of cerebrovascular diseases is urgent due to high prevalence and severity of this pathology. The objectives of the program were to analyze epidemiological indicators, risk factors, treatment patterns of chronic brain ischemia developed in
M Sitges et al.
Epilepsy research, 96(3), 257-266 (2011-07-09)
4-Aminopyridine (4-AP) is a convulsing agent that in vivo preferentially releases Glu, the most important excitatory amino acid neurotransmitter in the brain. Here the ionic dependence of 4-AP-induced Glu release and the effects of several of the most common antiepileptic
Yan-Ting Mao et al.
Die Pharmazie, 68(5), 381-382 (2013-06-28)
The purpose of the present study was to develop a novel transdermal vinpocetine patch containing a stable formulation and with good entrapment efficiency, and percutaneous absorption which via ethosome. Ethosome was found to be a more efficient delivery carrier with
Crystal L Lantz et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 30(5), 351-357 (2012-05-24)
There is growing evidence that deficits in neuronal plasticity underlie the cognitive problems seen in fetal alcohol spectrum disorders (FASD). However, the mechanisms behind these deficits are not clear. Here we test the effects of early alcohol exposure on ocular
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