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Key Documents

V1514

Sigma-Aldrich

Anti-VE-Cadherin (CD144) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-CD144, Anti-Cadherin-5, Anti-Vascular Endothelial Cadherin

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen ~130 kDa

Reattività contro le specie

human

tecniche

immunohistochemistry (frozen sections): 1:100 using acetone-fixed sections of human tonsil
western blot: 1:500 using whole extract of human umbilical vein endothelial cells (HUVEC).

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CDH5(1003)

Descrizione generale

Cadherin 5 (CDH5), also known as cadherin 144 (CD144), is encoded by the gene mapped to long arm of human chromosome 16. The encoded protein is expressed in endothelial cells, but it absent in normal epithelium.
VE-Cadherin (also designated vascular endothelial cadherin, cadherin-5, and cluster of differentiation 144 (CD144)) is a non-type I or II cadherin that is expressed on endothelial cells of all blood and lymphatic vessels, where it organizes intercellular adherens junctions.

Immunogeno

synthetic peptide corresponding to amino acids 91-110 of human VE-cadherin (CD144).

Applicazioni

Anti-VE-Cadherin (CD144) antibody produced in rabbit has been in following studies:
  • immunofluorescence imaging
  • western blotting
  • to weaken cell-cell junctions in human umbilical vein endothelial cells (HUVECs)
  • immunohistochemistry

Azioni biochim/fisiol

Cadherin 5 (CDH5)/CD144 plays an essential role in various cellular processes, such as regulation of cell adhesion, cell proliferation, cell survival, cell shape, cell motility. Additionally, it is also involved in the regulation of signaling pathways and transcriptional gene regulation. CD144/VE-cadherin is a core component of endothelial adherens junction, which plays a vital role in angiogenic sprouting by enhancing cell migration and cell elongation. CD144 expressed in glioblastoma multiforme (GBM) facilitates the transdifferentiation of glioblastoma stem like cells (GSCs) to endothelial cells and form blood vessels, under hypoxia condition. VE-cadherin induces endothelial cell-cell adhesion at adherens junctions (AJs). CD144 gene knockout results in loss of cell polarity and modification in vascular lumenal structure. CD144 inhibits the synthesis of CDH2 (also known as N-cadherin) in the endothelium.
VE-cadherin (CD144) interacts with β-catenin, plakoglobinand Adherens junction protein (p120ctn).

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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I clienti hanno visto anche

Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk P, et al.
The Journal of Experimental Medicine, 204(10), 2349-2349 (2007)
Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.
Kremmidiotis G
Genomics, 49, 467-471 (1998)
Effects of Morphology vs. Cell?Cell Interactions on Endothelial Cell Stiffness
Stroka KM and Aranda-Espinoza H.
Cellular and Molecular Bioengineering, 4, 9-27 (2011)
Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and
Venkiteswaran K, et al.
American Journal of Physiology. Cell Physiology (2002)
A lung-on-a-chip array with an integrated bio-inspired respiration mechanism.
Stucki AO
Lab on a chip, 15, 1302-1310 (2015)

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