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U100

Sigma-Aldrich

Urapidil hydrochloride

solid

Sinonimo/i:

6-[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C20H29N5O3 · HCl
Numero CAS:
64887-14-5
Peso molecolare:
423.94
Numero MDL:
MFCD00078601
Codice UNSPSC:
12352200
ID PubChem:
24277811
NACRES:
NA.77

Forma fisica

solid

Colore

white

Solubilità

H2O: soluble 25 mg/mL, clear, colorless to very faintly yellow

Stringa SMILE

Cl[H].COc1ccccc1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2

InChI

1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
KTMLZVUAXJERAT-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , HTR1A(3350)

Descrizione generale

The adrenoreceptor α 1a gene (ADRA1A) is mapped to human chromosome 8p21.2. It codes for an α-adrenergic receptor.

Azioni biochim/fisiol

α1-adrenoceptor antagonist; 5-HT1A serotonin receptor partial agonist; anti-hypertensive.
The adrenoreceptor α 1a gene (ADRA1A) participates in smooth muscle contraction. It is also required for vasoconstriction of blood vessels throughout the body such as the skin, gastrointestinal system, genitourinary system, kidney and brain. ADRA1A plays a major role in glycogenolysis and gluconeogenesis of adipose tissue in the liver. It also plays a crucial role in sympathetic nervous system.

Nota sulla preparazione

Urapidil hydrochloride is soluble in water at 25 mg/ml to yield a clear, colorless to very faint yellow solution.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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MiR-19b and miR-16 cooperatively signaling target the regulator ADRA1A in Hypertensive heart disease
He L and Huang C
Biomedicine and Pharmacotherapy, 91(1), 1178-1183 (2017)
Sakineh Pirahmadi et al.
Malaria journal, 18(1), 146-146 (2019-04-25)
Plasmodium falciparum parasite is the most deadly species of human malaria, and the development of an effective vaccine that prevents P. falciparum infection and transmission is a key target for malarial elimination and eradication programmes. P. falciparum cell-traversal protein for
Sakineh Pirahmadi et al.
Infection and immunity, 87(6) (2019-04-03)
Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (PfCelTOS) is an advanced vaccine candidate that has a crucial role in the traversal of the malaria parasite in both mosquito and mammalian hosts. As recombinant purified proteins are normally poor immunogens
K H Sanders et al.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 6(2), S65-S68 (1988-12-01)
The alpha-adrenoceptor antagonist urapidil influences central cardiovascular regulation, and this effect is unrelated to alpha-adrenoceptors. Since urapidil has appreciable affinity and selectivity for serotonin-1A (5HT1A) receptors, the activity of urapidil at these sites may be relevant for the centrally mediated
A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in chronic fatigue syndrome/myalgic encephalomyelitis
Johnston S, et al.
BMC Medical Genetics, 17(1), 79-79 (2016)
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