T2320

T0901317

≥98%

• Sinonimo/i: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
• Formula empirica (notazione di Hill): C₁₇H₁₂NSO₃F₉
• Numero CAS: 293754-55-9
• Peso molecolare: 481.33
• Numero MDL: MFCD03412028
• Codice UNSPSC: 12352106
• ID PubChem: 24900032
• NACRES: NA.25

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98%
• PM: 481.3
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2; SGIWFELWJPNFDH-UHFFFAOYSA-N
• Informazioni sul gene: human ... ABCA1(19) , NR1H2(7376) , NR1H3(10062)

Descrizione

Applicazioni

T0901317 has been used in LXR agonist study in order to observe the expression of all dietary cholesterol-regulated genes in mice. It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.

Azioni biochim/fisiol

LXR agonist whose treatment results in an LXR-dependent up-regulation of ABC1 gene expression

T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)