SRP6282

Nicotinamide N-Methyltransferase (hNNMT) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Sinonimo/i: NNMT
• Codice UNSPSC: 12352204
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Ricombinante: expressed in E. coli
• Saggio: ≥98% (SDS-PAGE)
• Forma fisica: liquid
• PM: 31.7 kDa (263 aa + NT 6xHis-tag)
• Confezionamento: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• Concentrazione: 3.42 mg/mL
• N° accesso UniProt: P40261
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... NNMT(4837)

Descrizione

Descrizione generale

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

Stato fisico

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable