SRP6050
HB-EGF from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinonimo/i:
DTR, DTSF, HEGFL, Heparin-binding EGF-like growth factor, Proheparin-binding EGF-like growth factor
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About This Item
Prodotti consigliati
Origine biologica
mouse
Ricombinante
expressed in E. coli
Saggio
≥95% (HPLC)
≥95% (SDS-PAGE)
Stato
lyophilized
Potenza
≥1x10^6 units/mg
PM
9.8 kDa
Confezionamento
pkg of 10 μg
Impurezze
≤1 EU/μg
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... HBEGF(15200)
Descrizione generale
HB-EGF (heparin-binding epidermal growth factor-like growth factor) belongs to the EGF family, and was first isolated as a secreted product from cultured human macrophages. It is produced as a precursor transmembrane protein (pro-HB-EGF), which is composed of EGF-like and heparin-binding domains. This precursor protein can be cleaved to produce a mature and soluble HB-EGF (sHB-EGF) form, and both these forms are active. It is expressed in various cell types including endothelial cells, epithelial cells, hematopoietic cells, and vascular smooth muscle cells.
Azioni biochim/fisiol
HB-EGF (heparin-binding epidermal growth factor-like growth factor) functions as a mitogen and a chemotactic factor. Studies in experimental necrotizing enterocolitis (NEC) show that enteral administration of this factor confers protection to intestines from tissue injury, facilitates migration and proliferation of enterocytes, and maintains intestinal stem cell (ISC) viability. In endothelial nitric oxide synthase (eNOS)-knockout mice, a reduction in nitric oxide bioavailability results in elevated HB-EGF expression, which might be play an important role in progressive diabetic nephropathy. In mice with inactivated HB-EGF gene in the hippocampal area, there is reduced neurogenesis in the subgranular zone (SGZ) of the dentate gyrus. These mice also show suppression of PSD-95 (post synaptic density)/NMDA (N-methyl-D-aspartate)-receptor-NR1 (NMDA receptor)/NR2B subunits, and the subsequent NMDA receptor signaling.
Stato fisico
Lyophilized with no additives
Nota sulla preparazione
Centrifuge the vial prior to opening.
Ricostituzione
It is recommended to reconstitute the lyophilized Mouse HB-EGF in sterile 18M-cm H?O not less than 100 μg/mL, which can then be further diluted to other aqueous solutions.
Altre note
DLEGTDLNLF KVAFSSKPQG LATPSKERNG KKKKKGKGLG KKRDPCLRKY KDYCIHGECR YLQEFRTPSC KCLPGYHGHR CHGLTL.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Heparin-binding EGF-like growth factor and enteric neural stem cell transplantation in the prevention of experimental necrotizing enterocolitis in mice.
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